ATP Production from VFAs (Acetate, Propionate, Butyrate)

Question

Moles of ATP produced by metabolism of 1 mole of acetate, propionate and butyrate are respectively:

Select an answer

Moles of ATP produced by metabolism of 1 mole of acetate, propionate and butyrate are respectively:

  1. 17, 10, 25
  2. 10, 16, 24
  3. 10, 17, 25 — Correct Answer
  4. 12, 18, 27
Explanation:
Correct Answer: 10, 17, 25

The ATP yield from complete oxidation of VFAs produced in the rumen:

  • Acetate (2C): 10 ATPs — enters TCA cycle as Acetyl-CoA after activation
  • Propionate (3C): 17 ATPs — most energy-efficient VFA per carbon; converted to succinyl-CoA via the succinate pathway, entering the TCA cycle
  • Butyrate (4C): 25 ATPs — converted to 2 molecules of Acetyl-CoA
Comparison with Other Substrates
  • Glucose (aerobic): 38 ATPs
  • Glycerol: 22 ATPs
  • Palmitic acid: 129 ATPs
1 mole ATP on hydrolysis yields:

7.3 kcal of free energy (ΔG = −7.3 kcal/mol)

📚 About this Topic — Animal Nutrition

This multiple choice question is from Animal Nutrition, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Nutrition to strengthen your preparation.

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