Major Ions of Intracellular Fluid

Question

The major cation & anion of intracellular fluid (ICF) are respectively:

Select an answer

The major cation & anion of intracellular fluid (ICF) are respectively:

  1. $Na^{+}$, $Cl^{-}$
  2. $K^{+}$, $PO_{4}^{-}$ — Correct Answer
  3. $Na^{+}$, $PO_{4}^{-}$
  4. None
Explanation:
Correct Answer: K⁺, PO₄³⁻

The major cation of Intracellular Fluid (ICF) is K⁺ (Potassium) and the major anion is PO₄³⁻ (Phosphate). Intracellular fluid is the fluid inside cells, comprising about 60–70% of total body water.

Fluid Compartment Electrolytes — Summary
Fluid Major Cation Major Anion
Extracellular Fluid (ECF) Na⁺ Cl⁻
Intracellular Fluid (ICF) K⁺ PO₄³⁻
Key Body Water Facts
  • Total body water: 60–70% of animal body
  • ICF makes up ~2/3 of total body water
  • ECF makes up ~1/3 of total body water
  • Na⁺/K⁺-ATPase pump maintains these gradients: pumps 3 Na⁺ out and 2 K⁺ in per cycle
Phosphorus — Special Role
  • Phosphorus plays an important role in nucleotide formation: ATP, ADP
  • Bone Ca:P ratio = 2:1
  • Normal blood phosphorus in ruminants: 4–8 mg/dl
Why Other Options Are Wrong
  • Na⁺, Cl⁻ → these are ECF electrolytes, not ICF
  • Na⁺, PO₄³⁻ → Na⁺ is ECF cation; PO₄³⁻ is ICF anion; the pairing is mixed/incorrect
  • None → incorrect; K⁺ and PO₄³⁻ are the established ICF electrolytes

📚 About this Topic — Animal Nutrition

This multiple choice question is from Animal Nutrition, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Nutrition to strengthen your preparation.

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