Topics:
Animal Physiology, Animal Refresher
Enzyme Responsible for Clot Lysis
Enzyme which is responsible for clot lysis is:
- Thromboplastin
- Thrombin
- Fibrin
- Plasmin — Correct Answer
Explanation:
Correct Answer: Plasmin
Plasmin is the principal enzyme responsible for fibrinolysis (clot lysis). It degrades fibrin clots into fibrin degradation products (FDPs).
Fibrinolysis Pathway
- Plasminogen (inactive) → Plasmin (active) — activated by tissue plasminogen activator (t-PA)
- Plasmin cleaves fibrin → fibrin degradation products → clot dissolves
- t-PA is used clinically as a thrombolytic agent (e.g., in stroke treatment).
Key Enzymes in Hemostasis
- Thrombin: Key enzyme in blood coagulation/hemostasis — converts fibrinogen → fibrin.
- Plasmin: Key enzyme in fibrinolysis — dissolves fibrin clot.
- Thromboplastin: Another name for Tissue Factor (Factor III); initiates extrinsic pathway.
📚 About this Topic — Animal Physiology
This multiple choice question is from Animal Physiology, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Physiology to strengthen your preparation.
