Topics:
Animal Physiology, Animal Refresher
Macrocytic Hyperchromic Anaemia – Deficiency
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Question (English)
Macrocytic and Hyperchromic anaemia is caused due to deficiency of:
- Vitamin B₁₂ only
- Folic acid only
- Iron
- Both Vitamin B₁₂ and Folic acid ✓ Correct
Explanation:
Correct Answer: Both Vitamin B₁₂ and Folic acid
Both Vitamin B₁₂ (Cobalamin) and Folic acid deficiencies cause Macrocytic Hyperchromic (Megaloblastic) Anaemia. These vitamins are essential for DNA synthesis — deficiency impairs RBC maturation, producing large immature RBCs.
Why Macrocytic Hyperchromic?
- Impaired DNA synthesis → RBCs fail to divide properly → abnormally large (macrocytic) cells.
- Hemoglobin synthesis is relatively unaffected → cells are packed with Hb → hyperchromic (darker).
Pernicious Anaemia — Special Case of Vitamin B₁₂ Deficiency
- Cause: Deficiency of Intrinsic Factor (IF) secreted by parietal cells of stomach → Vitamin B₁₂ cannot be absorbed in ileum.
- Type: Macrocytic Hyperchromic anaemia.
- Extrinsic (Castle's) factor: Vitamin B₁₂ itself (from diet).
- Intrinsic (Castle's) factor: Glycoprotein secreted by parietal cells of stomach → needed for B₁₂ absorption.
📚 About this Topic — Animal Physiology
This multiple choice question is from Animal Physiology, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Physiology to strengthen your preparation.
