Major Ions of Extracellular Fluid

Question

The major cation & anion of extracellular fluid (ECF) are respectively:

Select an answer

The major cation & anion of extracellular fluid (ECF) are respectively:

  1. $Na^{+}$, $Cl^{-}$ — Correct Answer
  2. $K^{+}$, $PO_{4}^{-}$
  3. $Na^{+}$, $PO_{4}^{-}$
  4. None
Explanation:
Correct Answer: Na⁺, Cl⁻

The major cation of Extracellular Fluid (ECF) is Na⁺ (Sodium) and the major anion is Cl⁻ (Chloride). ECF includes blood plasma, interstitial fluid, and lymph.

Fluid Compartment Electrolytes
Fluid Major Cation Major Anion
Extracellular Fluid (ECF) Na⁺ Cl⁻
Intracellular Fluid (ICF) K⁺ PO₄³⁻
Mineral Excretion Routes
  • Na⁺ and K⁺ → excreted mainly via urine
  • Ca and P → excreted mainly via faeces
  • Exception: In carnivores, P is excreted mainly via urine
Clinical Relevance
  • Hyponatraemia (low Na⁺ in ECF) → weakness, confusion, oedema
  • Normal blood Na⁺ in cattle: ~135–150 mEq/L
  • Na⁺ is the primary osmotic force maintaining ECF volume
Why Other Options Are Wrong
  • K⁺, PO₄³⁻ → major cation and anion of ICF, not ECF
  • Na⁺, PO₄³⁻ → Na⁺ is correct (ECF cation) but PO₄³⁻ is the ICF anion, not ECF anion
  • None → incorrect; Na⁺ and Cl⁻ are well-established ECF electrolytes

📚 About this Topic — Animal Nutrition

This multiple choice question is from Animal Nutrition, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Nutrition to strengthen your preparation.

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