Rate of VFA Absorption Order

Question

Rate of VFA absorption is:

Select an answer

Rate of VFA absorption is:

  1. Butyrate < Propionate < Acetate
  2. Propionate < Acetate < Butyrate
  3. Acetate < Propionate < Butyrate — Correct Answer
  4. None of the above
Explanation:
Correct Answer: Acetate < Propionate < Butyrate

The rate of VFA absorption across the rumen wall follows the order: Acetate < Propionate < Butyrate, meaning butyrate is absorbed fastest and acetate slowest.

Reason for This Order
  • VFAs are absorbed by passive diffusion in their undissociated (lipid-soluble) form.
  • Lipid solubility increases with chain length: Butyrate (C4) > Propionate (C3) > Acetate (C2).
  • Higher lipid solubility = faster passive diffusion through the lipid bilayer of rumen epithelium.
Mnemonic

'Bigger chain = Better absorption' — Butyrate has 4 carbons, propionate has 3, acetate has 2; hence butyrate is absorbed fastest.

Quantitative Contribution of VFAs in Rumen
  • Acetate: ~60–70% of total VFA (most abundant)
  • Propionate: ~15–20%
  • Butyrate: ~10–15% (least abundant but absorbed fastest)

VFAs together supply about 70% of the ruminant's total metabolizable energy requirement.

📚 About this Topic — Animal Physiology

This multiple choice question is from Animal Physiology, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Physiology to strengthen your preparation.

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