Topics:
Animal Refresher, Animal Reproduction
Secretions of Sertoli Cells
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Question (English)
Anti-Müllerian hormone (AMH), inhibin & androgen binding protein (ABP) are secreted by:
- Leydig cells
- Sertoli cells ✓ Correct
- Theca interna cells
- Granulosa cells
Explanation:
Correct Answer: Sertoli cells
Sertoli cells (sustentacular/nurse cells) of the seminiferous tubules secrete Anti-Müllerian Hormone (AMH), Inhibin, and Androgen Binding Protein (ABP).
Functions of Sertoli Cell Secretions
- AMH (Anti-Müllerian Hormone / Müllerian Inhibiting Substance — MIS): Secreted by Sertoli cells in the fetal testes — causes regression of the Müllerian (paramesonephric) duct in males during embryonic development. Without AMH, the Müllerian duct would develop into the female reproductive tract.
- Inhibin: Glycoprotein that selectively inhibits FSH secretion from the anterior pituitary — negative feedback control of spermatogenesis rate.
- Androgen Binding Protein (ABP): Binds testosterone within the seminiferous tubules — maintains high local testosterone concentration needed for spermatogenesis.
Leydig Cells (for contrast)
- Leydig cells (interstitial cells) secrete testosterone — the primary male sex hormone.
- Leydig cells = endocrine cells of the testes.
- Sertoli cells = exocrine + paracrine support cells (nurse cells). ✔
📚 About this Topic — Animal Refresher
This multiple choice question is from Animal Refresher, Animal Reproduction. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Refresher to strengthen your preparation.
