Topics:
Animal Physiology, Animal Refresher
Types of Antigen-Presenting Cells (APCs)
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Question (English)
Antigen-presenting cells (APCs) include:
- All the above ✓ Correct
- Dendritic cells only
- Macrophages only
- B-Lymphocytes only
Explanation:
Correct Answer: All the above
Antigen-Presenting Cells (APCs) are specialized immune cells that process protein antigens and present them on their surface using MHC class II molecules to activate T-helper (CD4⁺) cells. All three cell types function as APCs:
Three Types of Professional APCs
| APC Type | Location | Key Feature |
|---|---|---|
| Dendritic cells | Lymphoid organs, skin (Langerhans cells), mucosal surfaces | Most potent APCs; bridge innate and adaptive immunity |
| Macrophages | Tissues throughout body (Kupffer cells, microglia, etc.) | Also phagocytic; activate T-cells during chronic infection |
| B-Lymphocytes | Lymph nodes, spleen, blood | Present antigens that bind their surface immunoglobulins |
What APCs Do
APCs phagocytose/endocytose antigens → digest them → display peptide fragments on MHC class II → T-helper cells recognize these → T-helper cells activate B-cells and cytotoxic T-cells → adaptive immune response is initiated.
📚 About this Topic — Animal Physiology
This multiple choice question is from Animal Physiology, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Physiology to strengthen your preparation.
