Topics:
Animal Physiology, Animal Refresher
Site of Secretion of Intrinsic Castle (Gastric) Factor
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Question (English)
Intrinsic Castle (gastric) factor is secreted by:
- Parietal cells of stomach ✓ Correct
- Chief cells of stomach
- G-cells of stomach
- None of the above
Explanation:
Correct Answer: Parietal cells of stomach
The intrinsic Castle factor (gastric intrinsic factor / GIF) is a glycoprotein secreted by the parietal cells (oxyntic cells) of the gastric mucosa. It binds to dietary Vitamin B12 in the stomach, and the resulting complex is absorbed in the terminal ileum via specific receptors (cubam).
Three Types of Gastric Secretory Cells
| Cell Type | Location | Secretion |
|---|---|---|
| Parietal cells (Oxyntic cells) | Body/fundus of stomach | HCl + Intrinsic factor (Castle) |
| Chief cells (Peptic cells / Zymogen cells) | Body/fundus of stomach | Pepsinogen (activated to pepsin by HCl) |
| G-cells | Antrum of stomach | Gastrin (stimulates HCl and pepsinogen secretion) |
Why Other Options Are Wrong
- Chief cells → Secrete pepsinogen, not intrinsic factor.
- G-cells → Secrete gastrin hormone, not intrinsic factor.
- None → Incorrect; parietal cells clearly secrete intrinsic factor alongside HCl.
📚 About this Topic — Animal Physiology
This multiple choice question is from Animal Physiology, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Physiology to strengthen your preparation.
