Topics:
Animal Physiology, Animal Refresher
Haemophilia and Deficient Clotting Factor Pairs
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Question (English)
Which of the following pair(s) of disease and its deficient clotting factor is/are correctly matched?
- Haemophilia A: Factor VIII only
- Haemophilia B: Factor IX only
- Pernicious anaemia: Vitamin B₁₂ only
- All the above — Haemophilia A: VIII, Haemophilia B: IX, and Pernicious anaemia: B₁₂ ✓ Correct
Explanation:
Correct Answer: All the above
Haemophilia
- Haemophilia A: Deficiency of Factor VIII (Antihemophilic factor A / AHG). Most common type. X-linked recessive disorder.
- Haemophilia B (Christmas Disease): Deficiency of Factor IX (Christmas factor / Antihemophilic factor B / PTC). X-linked recessive.
- Both Haemophilia A and B affect the intrinsic pathway of clotting.
Pernicious Anaemia
- Cause: Deficiency of Vitamin B₁₂ due to lack of Intrinsic Factor (Castle's intrinsic factor — secreted by parietal cells of stomach).
- Type: Macrocytic Hyperchromic anaemia.
- Vitamin B₁₂ is the extrinsic (Castle's) factor; Intrinsic Factor (IF) is the glycoprotein needed for its absorption in the terminal ileum.
📚 About this Topic — Animal Physiology
This multiple choice question is from Animal Physiology, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Physiology to strengthen your preparation.
