Topics:
Animal Physiology, Animal Refresher
Type of Pernicious Anaemia
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Question (English)
Pernicious anaemia is which type of anaemia?
- Macrocytic hyperchromic ✓ Correct
- Microcytic hypochromic
- Macrocytic normochromic
- Normocytic normochromic
Explanation:
Correct Answer: Macrocytic Hyperchromic
Pernicious anaemia is a type of Macrocytic Hyperchromic anaemia (also called Megaloblastic anaemia). It is caused by Vitamin B₁₂ deficiency due to absent/deficient Intrinsic Factor (IF) from parietal cells.
Pathophysiology
- No IF → Vitamin B₁₂ not absorbed in terminal ileum → deficiency
- Vitamin B₁₂ is needed for DNA synthesis and maturation of RBC precursors
- Without it, RBC precursors cannot divide properly → large, immature megaloblasts are produced
- Large cells = Macrocytic; packed with Hb = Hyperchromic
Anaemia Type Quick Reference
| Anaemia | Type | Cause |
|---|---|---|
| Pernicious | Macrocytic Hyperchromic | Vitamin B₁₂ / Folic acid deficiency |
| Iron deficiency | Microcytic Hypochromic | Iron deficiency |
| Chronic disease | Normocytic Normochromic | Chronic inflammatory conditions |
📚 About this Topic — Animal Physiology
This multiple choice question is from Animal Physiology, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Physiology to strengthen your preparation.
