Primary Site of Drug Biotransformation
The primary site of drug biotransformation in the body is:
- Intestine
- Lung
- Kidney
- Liver — Correct Answer
Correct Answer: Liver
Although every tissue has some ability to metabolize drugs, the liver is the principal organ of drug metabolism (biotransformation). The general purpose is to render non-polar lipid-soluble compounds into polar water-soluble compounds for easy excretion.
Other Important Sites
- Gastrointestinal tract
- Lungs
- Skin
- Kidneys
Key Enzyme System
The Mixed Function Oxidases (MFO) or CYP 450 enzymes (Cytochrome P450) in the smooth endoplasmic reticulum of the liver are the most important drug-metabolizing enzymes. They require molecular O₂ and NADPH.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
