Biotransformation Deficiency in Cats
Cats are deficient in which phase-II biotransformation reaction?
- Sulfation
- Methylation
- Glucuronidation — Correct Answer
- Acetylation
Explanation:
Correct Answer: Glucuronidation
Cats are deficient in glucuronidation due to low levels of glucuronyl transferase. This makes many drugs particularly toxic to cats (e.g. paracetamol/acetaminophen, aspirin, chloramphenicol) at doses that are safe for dogs.
Species Differences in Biotransformation
- Cats: Deficient in glucuronidation (low glucuronyl transferase).
- Dogs: Lack acetylation capacity.
- Pigs: Have low capacity for sulfation.
- Rabbits: Possess atropinase — therefore do not suffer toxicity from atropine.
Clinical Significance
Species differences in biotransformation are critically important in veterinary pharmacology as they determine drug doses, toxicities, and drug selection for different species.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
