Zero-Order Drug Elimination Kinetics
In zero-order kinetics, drug elimination occurs as:
- Constant fraction/time
- Increasing amount/time
- Constant amount/time — Correct Answer
- Decreasing fraction/time
Explanation:
Correct Answer: A constant amount per unit time
Zero-order (nonlinear) kinetics: The rate of elimination is constant irrespective of concentration — a constant amount of drug is eliminated per unit time. This occurs when saturable mechanisms of elimination are operating, particularly in toxicity or at very high doses.
Comparison
- First-order (linear) kinetics: Rate of elimination is proportional to plasma concentration — a constant fraction eliminated per unit time. Occurs for most drugs under normal conditions.
- At very high doses, reaction can change from first-order to zero-order → concentration increases disproportionately with increase in dose.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
