Conditions for Kreb’s Cycle

Question

Kreb's cycle takes place in mitochondria under:

Select an answer

Kreb's cycle takes place in mitochondria under:

  1. Aerobic condition only — Correct Answer
  2. Anaerobic condition only
  3. Both a & b
  4. None
Explanation:
Correct Answer: Aerobic condition only

The Krebs Cycle (Citric Acid Cycle / TCA cycle) occurs in the mitochondrial matrix and requires oxygen — it is strictly an aerobic process. Without oxygen, NADH and FADH₂ produced cannot be reoxidized by the electron transport chain, so the cycle cannot continue.

Kreb's Cycle vs Glycolysis — Comparison
Feature Glycolysis Kreb's Cycle
Location Cytoplasm Mitochondrial matrix
Oxygen requirement Not required (runs anaerobically too) Required (strictly aerobic)
Substrate Glucose Acetyl CoA
ATP yield per turn 2 ATP (net) 1 GTP + 3 NADH + 1 FADH₂ per turn
Why Kreb's Cycle is Aerobic Only
  • NADH and FADH₂ generated by the cycle must be reoxidized by the Electron Transport Chain (ETC).
  • ETC uses O₂ as the final electron acceptor → produces H₂O.
  • Without O₂, NADH accumulates → Krebs cycle intermediates back up → cycle stops.
Why Other Options Are Wrong
  • Anaerobic only → incorrect; the TCA cycle cannot function without oxygen.
  • Both aerobic and anaerobic → incorrect; only glycolysis can function anaerobically.
  • None → aerobic only is the correct answer.

📚 About this Topic — Animal Nutrition

This multiple choice question is from Animal Nutrition, Animal Refresher. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Animal Nutrition to strengthen your preparation.

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