Plasma Protein Binding of Acidic Drugs
Acidic drugs are primarily bound to which plasma protein?
- Fibrinogen
- Globulin
- Albumin — Correct Answer
- α1-acid glycoprotein
Explanation:
Correct Answer: Albumin
Acidic drugs are bound primarily to albumin. Basic drugs are bound primarily to α1-acid glycoprotein.
Examples of Albumin-Bound Drugs
- NSAIDs
- Barbiturates
- Phenytoin
- Penicillins
- Tetracyclines
Examples of α1-Acid Glycoprotein-Bound Drugs
- Verapamil
- Lidocaine
- Bupivacaine
- Quinidine
- Prazosin
Clinical Significance
Only the unbound (free) fraction of a drug can diffuse out of capillaries into tissues and exert pharmacologic effects. Drug-protein binding is reversible and follows the law of mass action.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
