Probenecid-Penicillin Pharmacokinetic Interaction
Probenecid antagonizes penicillin by competing for which pharmacokinetic process?
- Excretion — Correct Answer
- Absorption
- Biotransformation
- Distribution
Explanation:
Correct Answer: Excretion
Probenecid antagonizes penicillin excretion by competing for the same binding site in renal tubular secretion. This is an example of pharmacokinetic antagonism at the level of excretion.
Examples of Pharmacokinetic Antagonism
- Absorption: Antacids prevent absorption of other drugs.
- Distribution: Aspirin displaces warfarin from its plasma protein binding site.
- Biotransformation: Microsomal inducers/inhibitors modulate metabolism of other drugs.
- Excretion: Probenecid competes with penicillin for renal tubular secretion — increases penicillin's plasma levels and prolongs its action (clinically exploited to maintain therapeutic penicillin levels).
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
