Mechanism of Cyproheptadine Appetite Stimulation
Cyproheptadine stimulates appetite in cats due to its action as:
- Muscarinic agonist, gastric
- Glucocorticoid euphoria
- 5-HT/H1 antagonist, satiety — Correct Answer
- Dopamine agonist, appetite
Explanation:
Correct Answer: Serotonin and H1 antagonist suppressing the satiety center
Cyproheptadine acts as both a serotonin and histamine (H1) antagonist, suppressing the satiety center in the hypothalamus. It stimulates appetite in cats and in humans, but NOT in dogs.
Adverse Effects of Cyproheptadine
CNS excitement and marked aggressive behaviour in cats.
Other Appetite Stimulants
- Benzodiazepines (Diazepam, Oxazepam): Antiserotonergic → depresses satiety center; used most in cats and horses.
- Glucocorticoids (Prednisolone, Dexamethasone): Stimulate appetite via glucocorticoid-induced euphoria.
- Bitters (Nux vomica, chiretta, ginger): Used in large animals as tonics.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
