Type of Drug Synergism of Sulfonamide + Trimethoprim
Sulfonamide + Trimethoprim combination is an example of:
- Competitive antagonism
- Simple additive synergism
- Supraadditive (potentiation) — Correct Answer
- Non-competitive antagonism
Explanation:
Correct Answer: Supraadditive (Potentiation)
Sulfonamide + Trimethoprim is the classic example of supraadditive (potentiation) synergism — the net effect is greater than the sum of individual effects (1+1 = 3). This combination converts a bacteriostatic effect into a bactericidal effect by sequential blockade of folate synthesis.
Types of Synergism
- Additive (1+1=2): Sum of individual effects only. E.g. Aspirin + paracetamol (analgesic + antipyretic).
- Supraadditive/Potentiation (1+1=3): More than sum of individual effects. E.g. Sulfonamide + Trimethoprim; ACh + Physostigmine.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
