Effect of Drug Redistribution from Brain
Redistribution of highly fat-soluble drugs initially taken up by the brain leads to:
- Complete elimination
- Enhanced toxicity
- Plasma fall, action lost — Correct Answer
- Plasma rise, prolonged action
Correct Answer: Fall in plasma concentration and loss of drug action
Highly fat-soluble drugs (e.g. thiopentone) are initially taken up by the brain, heart, and kidney (highly perfused tissues). They later get deposited in less vascular tissues — muscle and fat. On redistribution, plasma concentration falls, leading to loss of drug action.
Clinical Example: Thiopentone
Thiopentone produces ultra-short anesthesia due to redistribution from the brain to adipose tissue — NOT because of rapid metabolism. On repeated doses, fat depots fill up leading to longer duration of action (accumulation effect).
📚 About this Topic — Veterinary Pharmacology and Toxicology
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