pH Condition for Sucralfate Polymerization
Sucralfate polymerizes to a viscous gel at a pH:
- Equal to 4
- Greater than 4
- Less than 4 — Correct Answer
- Greater than 7
Explanation:
Correct Answer: Less than 4
Sucralfate is a complex of sulfated sucrose and aluminum hydroxide (known as a 'gastric band aid'). It polymerizes to a viscous gel at a pH less than 4, combining with proteins and adhering to the ulcer base to form an acid- and pepsin-resistant barrier.
Key Facts About Sucralfate
- Requires an acidic environment to be effective — do NOT co-administer antacids.
- Does NOT decrease gastric acid secretion or neutralize acid.
- As effective as cimetidine or antacids at healing peptic ulcers.
- Adverse effect: Constipation with long-term therapy.
- Interferes with absorption of tetracyclines, fluoroquinolones, cimetidine, phenytoin, digoxin.
- Used in dogs, cats and foals for gastric and duodenal ulcers.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
