Target of Proton Pump Inhibitors
Proton pump inhibitors irreversibly inhibit:
- K⁺H⁺-ATPase, parietal cells — Correct Answer
- Muscarinic, gastric mucosa
- Na⁺K⁺-ATPase, gastric
- H2 receptors, parietal
Explanation:
Correct Answer: K⁺H⁺-ATPase proton pump in parietal cells
Proton pump inhibitors (PPIs) — omeprazole, lansoprazole, pantoprazole — irreversibly inhibit K⁺H⁺-ATPase (the proton pump) in gastrointestinal parietal cells, preventing entry of H⁺ ions into the gastric lumen.
Key Features of PPIs
- Break down in acidic stomach → must be given as enteric coated preparations orally.
- Short plasma half-lives but long-acting (due to irreversible binding).
- Have antimicrobial activity against H. pylori.
- Heal duodenal ulcers more rapidly than H2 antagonists.
- Used for ulcers refractory to other treatments and reflux esophagitis.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
