Unique Property of Cimetidine Among H2 Blockers
Cimetidine is different from other H2 blockers because it:
- No gastric acid effect
- Injection only
- More potent, ranitidine
- Hepatic metabolism inhibitor, antiandrogenic — Correct Answer
Explanation:
Correct Answer: Inhibits hepatic drug metabolism and has antiandrogenic effects
Cimetidine uniquely exhibits antiandrogenic properties (decreased sperm count, gynecomastia) and inhibits cytochrome P450 activity — leading to potential drug interactions by reducing the metabolism of co-administered drugs.
This Feature Is NOT Seen With
- Ranitidine
- Famotidine
- Nizatidine
Mechanism of H2 Blockers
Histamine from enterochromaffin-like cells stimulates parietal H2 receptors → activates cAMP → activates H⁺K⁺-ATPase → increased H⁺ in gastric lumen. H2 blockers block this pathway, reducing acid secretion.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
