Why Drug Allergy Requires a Priming Dose
Drug allergy (hypersensitivity) requires a priming dose because:
- Receptor depletion
- Hapten, antibody production — Correct Answer
- Activated on first exposure
- Enzyme induction
Explanation:
Correct Answer: Drug acts as a hapten and stimulates antibody production
Drug allergy is an immunologically mediated reaction. The drug acts as an antigen (hapten) and stimulates the body to produce antibodies against it after the first (priming) dose. The second dose then triggers a violent allergic reaction.
Types of Drug Hypersensitivity
- Type I — Anaphylactic (Immediate): Itching, urticaria, asthma — within minutes.
- Type II — Cytolytic: Decrease of blood cells and organ damage.
- Type III — Arthus (Immune complex): Serum sickness, fever, arthralgia.
- Type IV — Delayed hypersensitivity: Takes more than 12 hours — contact dermatitis, rashes, fever.
Common Culprit Drugs
Penicillin, sulfonamide, tetracycline, salicylates, quinolones, anti-TB drugs.
📚 About this Topic — Veterinary Pharmacology and Toxicology
This multiple choice question is from Veterinary Pharmacology and Toxicology, Veterinary Science. It has 4 options with a detailed explanation of the correct answer. Practice more MCQs from Veterinary Pharmacology and Toxicology to strengthen your preparation.
